1-Methoxy-3-(methylsulfonyl)benzene → 3-(Methylsulfonyl)phenol

HRID 1798799

反応式

HRID 1798799 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:4]=1>Br.C(O)(=O)C>[CH3:12][S:9]([C:5]1[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=1)(=[O:10])=[O:11]

参加物

4

反応物 1

HCID 2596501-Methoxy-3-(methylsulfonyl)benzene

生成物 1

HCID 6375563-(Methylsulfonyl)phenol

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒

実験手順

1-Methoxy-3-(methylsulfonyl)benzene (300 mg, 1.61 mmol) was suspended in 1.6 mL aqueous hydrobromic acid (48% w/w) and 1.6 mL acetic acid. The mixture was heated under reflux for 24 hours. The reaction was cooled back to room temperature and concentrated. The residue was purified by column chromatography through a 40 gram biotage silica gel cartridge eluting with 40-70% ethyl acetate/hexanes (gradient) to give the product as white solid. LRMS calc: 172.0; obs: 173.2 (M+1).

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography through a 40 gram biotage silica gel cartridge
  5. washeluting with 40-70% ethyl acetate/hexanes (gradient)

出典と根拠

ORDレコード
ord-11b48ec471dc4eb293cd2916ea000e55
出典データセット
uspto-grants-2013_01
特許番号
US08343990B2

関連ノート

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