Trifluoroacetic acid → 3-(5-Methyl-1,3,4-oxadiazol-2-yl)phenol
反応式
COC1C=CC(C[O:8][C:9]2[CH:10]=[C:11]([C:15]3[O:16][C:17]([CH3:20])=[N:18][N:19]=3)[CH:12]=[CH:13][CH:14]=2)=CC=1.C(O)(C(F)(F)F)=O>>[CH3:20][C:17]1[O:16][C:15]([C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=2)=[N:19][N:18]=1参加物
3
実験手順
2-{3-[(4-Methoxybenzyl)oxy]phenyl}-5-methyl-1,3,4-oxadiazole (100 mg, 0.338 mmol) was treated with 0.5 mL TFA and was stirred at room temperature for 10 min. Excess TFA was removed under vacuum and the residue was purified by column chromatography using a 24 gram biotage silica gel cartridge eluting with 20-50% ethyl acetate/hexanes (gradient) to give the product as white solid. LRMS calc: 176.1; obs: 177.2 (M+1).
後処理
- customExcess TFA was removed under vacuum
- customthe residue was purified by column chromatography
- washeluting with 20-50% ethyl acetate/hexanes (gradient)
出典と根拠
- ORDレコード
- ord-e5db634352fa4d798eb663fcfaa7623b
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08343990B2
反応ノート
読み込み中…