Chlorosulfonic acid → HCID 58433497、化合物

HRID 1798957ノート

反応式

HRID 1798957 の反応式
[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:26][S:27](O)(=[O:29])=[O:28]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][C:23]([S:27]([Cl:26])(=[O:29])=[O:28])=[CH:22][CH:21]=3)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

参加物

4

反応物 2

HCID 24638Chlorosulfonic acidHCID 58433490HCID 58433490、化合物

生成物 1

HCID 58433497HCID 58433497、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

185 mg of (3-Chloro-5-trifluoromethyl-pyridin-2-yl)-(1-phenyl-cyclohexylmethyl)-amine were dissolved in 15 ml of methylenchloride and 0.14 ml of chlorosulfonic acid were added. The reaction mixture was stirred at room temperature for 4 days and than poured on ice water (20 ml). The organic layer was separated, washed twice with 50 ml of brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 194 mg g of the crude product.

後処理

  1. additionthan poured on ice water (20 ml)
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml of brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-d9707b838f96458a80063c53f79f016e
出典データセット
uspto-grants-2013_01
特許番号
US08344004B2

反応ノート

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