m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

HRID 1799542

反応式

HRID 1799542 の反応式
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:20]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 7015327Methyl 2-methylnicotinate

生成物 1

HCID 20163965Methyl 2-methylnicotinate 1-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methyl 2-methylpyridine-3-carboxylate (10 g, 66.2 mmol) was taken up in DCM (140 mL) and mCPBA (16.31 g, 72.8 mmol) was added. The resulting solution was stirred at room temperature overnight. The reaction mixture was purified directly by silica gel chromatography (0-20% MeOH/EtOAc) to afford the title compound as a beige solid.

後処理

  1. customThe reaction mixture was purified directly by silica gel chromatography (0-20% MeOH/EtOAc)

出典と根拠

ORDレコード
ord-5826699f908e498497767f14fa30e8d5
出典データセット
uspto-grants-2013_01
特許番号
US08344144B2

関連ノート

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