m-Chloroperbenzoic acid → 2-(Chloromethyl)-3-(methoxycarbonyl)pyridine 1-oxide

HRID 1799544ノート

反応式

HRID 1799544 の反応式
[Cl:1][CH2:2][C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1.C1C=C(Cl)C=C(C(OO)=[O:21])C=1>C(Cl)Cl>[Cl:1][CH2:2][C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=[CH:5][N+:4]=1[O-:21]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 19081344Methyl 2-(chloromethyl)pyridine-3-carboxylate

生成物 1

HCID 582166522-(Chloromethyl)-3-(methoxycarbonyl)pyridine 1-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methyl 2-(chloromethyl)pyridine-3-carboxylate (4.45 g, 23.98 mmol) was taken up in DCM (50 mL) and mCPBA (5.91 g, 26.4 mmol) was added. The resulting solution was stirred at room temperature overnight. The reaction mixture was then purified directly by silica gel chromatography (0-20% MeOH/EtOAe) to give methyl 2-(chloromethyl)pyridine-3-carboxylate 1-oxide as a white solid.

後処理

  1. customThe reaction mixture was then purified directly by silica gel chromatography (0-20% MeOH/EtOAe)

出典と根拠

ORDレコード
ord-f9239f87dfc24a56b8a9ae73508168ab
出典データセット
uspto-grants-2013_01
特許番号
US08344144B2

反応ノート

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