Methylamine → 2-chloro-6-methyl-5H,6H,7H-pyrrolo(3,4-b)pyridin-7-one
反応式
Br[CH2:2][C:3]1[C:4]([C:10]([O:12]C)=O)=[N:5][C:6]([Cl:9])=[CH:7][CH:8]=1.[CH3:14][NH2:15].C1COCC1>>[Cl:9][C:6]1[N:5]=[C:4]2[C:10](=[O:12])[N:15]([CH3:14])[CH2:2][C:3]2=[CH:8][CH:7]=1参加物
4
実験手順
2-Chloro-6-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one was prepared according to the general procedure in Example 7 Step 1 using methyl 3-(bromomethyl)-6-chloropyridine-2-carboxylate (0.40 g, 1.49 mmol) and methylamine, 2 M in THF (10 mL, 20 mmol) as the starting materials.
出典と根拠
- ORDレコード
- ord-87ff2f77baeb4e97b85b6ddc2fa51845
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08344144B2
反応ノート
読み込み中…