3-Hydroxyazetidine hydrochloride → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({2-[(3-hydroxyazetidin-1-yl)carbonyl]imidazo[1,2-b]pyridazin-6-yl}amino)thiophene-3-carboxamide

反応式

[NH2:1][C:2]([C:4]1[CH:8]=[C:7]([C:9]2[C:14]([F:15])=[CH:13][C:12]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:11][C:10]=2[F:20])[S:6][C:5]=1[NH:21][C:22]1[CH:23]=[CH:24][C:25]2[N:26]([CH:28]=[C:29]([C:31](OCC)=[O:32])[N:30]=2)[N:27]=1)=[O:3].C[Al](C)C.Cl.[OH:41][CH:42]1[CH2:45][NH:44][CH2:43]1>O1CCCC1>[F:15][C:14]1[CH:13]=[C:12]([C:16]([OH:19])([CH3:18])[CH3:17])[CH:11]=[C:10]([F:20])[C:9]=1[C:7]1[S:6][C:5]([NH:21][C:22]2[CH:23]=[CH:24][C:25]3[N:26]([CH:28]=[C:29]([C:31]([N:44]4[CH2:45][CH:42]([OH:41])[CH2:43]4)=[O:32])[N:30]=3)[N:27]=2)=[C:4]([C:2]([NH2:1])=[O:3])[CH:8]=1