Tetrahydrofuran → Tert-butyl 3-(6-aminopyridin-3-yloxy)phenylcarbamate

HRID 1800397

反応式

HRID 1800397 の反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][C:15]2[CH:16]=[N:17][C:18]([N+:21]([O-])=O)=[CH:19][CH:20]=2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].O1CCCC1>C(OCC)(=O)C.[C].[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][C:15]2[CH:16]=[N:17][C:18]([NH2:21])=[CH:19][CH:20]=2)[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 57749209Tert-butyl 3-(6-nitropyridin-3-yloxy)phenylcarbamate

生成物 1

HCID 57749334Tert-butyl 3-(6-aminopyridin-3-yloxy)phenylcarbamate収率 108.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of tert-butyl{3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate (6.00 g, 18.1 mmol) in ethyl acetate (500 mL)/tetrahydrofuran (150 mL) was added 10% palladium-carbon (600 mg), and the mixture was stirred at room temperature for 16 hr under a hydrogen atmosphere (1.0 atm). The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (5.9 g, quantitative) as a brown oil. The obtained compound was used for the next reaction without further purification.

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-da3b8d855b8244b68a2a309d96bc16fc
出典データセット
uspto-grants-2013_01
特許番号
US08344135B2

関連ノート

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