Hydrogen chloride-ethyl acetate → 6-Azaspiro(2.5)octane hydrochloride

HRID 1800604ノート

反応式

HRID 1800604 の反応式
[CH2:1]1[C:3]2([CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]2)[CH2:2]1.[ClH:16].C(OCC)(=O)C>O1CCCC1>[ClH:16].[CH2:2]1[C:3]2([CH2:8][CH2:7][NH:6][CH2:5][CH2:4]2)[CH2:1]1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 51358341Tert-butyl 6-azaspiro[2.5]octane-6-carboxylate

生成物 1

HCID 545931876-Azaspiro(2.5)octane hydrochloride収率 85.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

Tert-butyl 6-azaspiro[2.5]octane-6-carboxylate (261 mg, 1.23 mmol) was dissolved in tetrahydrofuran (5 mL), 4N hydrochloric acid/ethyl acetate solution (2 mL, 8.00 mmol) was added, and the mixture was stirred at 50° C. for 24 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (155 mg, 85%) as white crystals.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e4b3a222fdea47e4ac21dbf20233476a
出典データセット
uspto-grants-2013_01
特許番号
US08344135B2

反応ノート

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