HCID 531812、化合物 → N-(3-aminophenyl)-3-(trifluoromethyl)benzamide

HRID 1800664ノート

反応式

HRID 1800664 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:22])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>O1CCCC1>[NH2:1][C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:22])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=2)[CH:7]=[CH:8][CH:9]=1

参加物

3

反応物 1

HCID 531812HCID 531812、化合物

生成物 1

HCID 20117519N-(3-aminophenyl)-3-(trifluoromethyl)benzamide収率 66%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of N-(3-nitrophenyl)-3-(trifluoromethyl)benzamide (30.0 g, 96.7 mmol) in tetrahydrofuran (300 mL) was slowly added with heating under reflux aqueous sodium hydrosulfite (97.8 g, 562 mmol) solution (500 mL), and the obtained two-layer solution was vigorously stirred with heating under reflux for 2 days. After cooling the reaction solution to room temperature, the aqueous layer was separated and extracted with ethyl acetate (150 mL×2). The organic layer separated earlier was diluted with ethyl acetate (350 mL), and washed with saturated aqueous sodium hydrogen carbonate solution (150 mL×2) and saturated brine (100 mL). The collected organic layer was washed with saturated aqueous sodium hydrogen carbonate solution (150 mL×2) and saturated brine (150 mL), and dried over anhydrous magnesium sulfate. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (17.8 g, 66%) as a pale-brown solid.

後処理

  1. temperaturewith heating
  2. temperatureunder reflux for 2 days
  3. customthe aqueous layer was separated
  4. extractionextracted with ethyl acetate (150 mL×2)
  5. customThe organic layer separated earlier
  6. additionwas diluted with ethyl acetate (350 mL)
  7. washwashed with saturated aqueous sodium hydrogen carbonate solution (150 mL×2) and saturated brine (100 mL)
  8. washThe collected organic layer was washed with saturated aqueous sodium hydrogen carbonate solution (150 mL×2) and saturated brine (150 mL)
  9. dry with materialdried over anhydrous magnesium sulfate
  10. filtrationThe insoluble material was filtered off
  11. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-cda861dc104547c4b5835c20e048ee9e
出典データセット
uspto-grants-2013_01
特許番号
US08344135B2

反応ノート

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