Methanol → 2-Chloro-3-(1-cyanocyclopropyl)benzoic acid
反応式
[Cl:1][C:2]1[C:11]([C:12]2([C:15]#[N:16])[CH2:14][CH2:13]2)=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].CO.O.O.[OH-].[Li+]>O1CCCC1>[Cl:1][C:2]1[C:11]([C:12]2([C:15]#[N:16])[CH2:14][CH2:13]2)=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]参加物
6
実験手順
To a solution of methyl 2-chloro-3-(1-cyanocyclopropyl)benzoate (13.5 g, 57.3 mmol) in tetrahydrofuran (180 mL)/methanol (60 mL)/water (60 mL) was added lithium hydroxide monohydrate (3.62 g, 86.3 mmol), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and to the obtained residue was dropwise added 6N hydrochloric acid (20 mL). The precipitate was collected by filtration, and washed with water to give the title compound (11.4 g, 90%) as white crystals.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- filtrationThe precipitate was collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-adc0abffecba4cad91a9a55f75f56335
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08344135B2
反応ノート
読み込み中…