Tert-butyl 3-fluoro-4-(thiazol-4-yl)phenylcarbamate → 3-Fluoro-4-(thiazol-4-yl)benzenamine

HRID 1802006ノート

反応式

HRID 1802006 の反応式
[F:1][C:2]1[CH:3]=[C:4]([NH:13]C(=O)OC(C)(C)C)[CH:5]=[CH:6][C:7]=1[C:8]1[N:9]=[CH:10][S:11][CH:12]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:3]=[C:4]([NH2:13])[CH:5]=[CH:6][C:7]=1[C:8]1[N:9]=[CH:10][S:11][CH:12]=1

参加物

4

反応物 1

HCID 57471879Tert-butyl 3-fluoro-4-(thiazol-4-yl)phenylcarbamate

生成物 1

HCID 574718803-Fluoro-4-(thiazol-4-yl)benzenamine収率 81.1%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of tert-butyl 3-fluoro-4-(thiazol-4-yl)phenylcarbamate (270 mg, 0.92 mmol) in CH2Cl2 (2 mL) and TFA (4 mL) was stirred at room temperature for 60 min. It was then concentrated in vacuo. The residue was dissolved in CH2Cl2 (20 mL), which was washed with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give 3-fluoro-4-(thiazol-4-yl)benzenamine (145 mg) as free base. MS195.2 (M+H)

後処理

  1. concentrationIt was then concentrated in vacuo
  2. dissolutionThe residue was dissolved in CH2Cl2 (20 mL)
  3. washwhich was washed with 5% NaHCO3
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-be799e093b0643fc8390efa9b1b49f63
出典データセット
uspto-grants-2013_01
特許番号
US08349860B2

反応ノート

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