1-(2-fluoro-4-nitrophenyl)-1H-imidazole → 3-fluoro-4-(1H-imidazol-1-yl)aniline

HRID 1802012ノート

反応式

HRID 1802012 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1>CO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

4

反応物 1

HCID 53061531-(2-fluoro-4-nitrophenyl)-1H-imidazole

生成物 1

HCID 103749763-fluoro-4-(1H-imidazol-1-yl)aniline収率 88.5%

試薬・触媒・溶媒 2

HCID 887Methanol触媒HCID 23938Palladium触媒

実験手順

A mixture of 1-(2-fluoro-4-nitrophenyl)-1H-imidazole (1.81 g, 8.74 mmol) and Pd—C (10%, 0.200 g) in MeOH (20 mL) (containing 10 drops of 6N HCl) was hydrogenated under balloon H2 overnight. The mixture was filtered through celite. The filtrate was concentrated in vacuo. The residue was dried on vacuum to give 3-fluoro-4-(1H-imidazol-1-yl)benzenamine as a solid (1.37 g). MS178.3 (M+H)

後処理

  1. customwas hydrogenated under balloon H2 overnight
  2. filtrationThe mixture was filtered through celite
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was dried on vacuum

出典と根拠

ORDレコード
ord-ba7a3d2679274d2493f6c090e38e9731
出典データセット
uspto-grants-2013_01
特許番号
US08349860B2

反応ノート

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