Trifluoroacetic acid → Trifluoroacetic acid

HRID 1802051

反応式

HRID 1802051 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([NH:7]C(=O)OC(C)(C)C)[S:5][CH:6]=1.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:7])[S:5][CH:6]=1.[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 574719832-(Boc-amino)-4-methylthiophene

生成物 2

HCID 6422Trifluoroacetic acidHCID 122311924-Methylthiophen-2-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of tert-butyl 4-methylthiophen-2-ylcarbamate (0.880 g, 4.13 mmol) in CH2Cl2 (8 mL) and TFA (6 mL) wad stirred at room temperature for 3 h. Solvents was removed in vacuo to give 4-methylthiophen-2-amine as trifluoroacetic acid salt (0.920 g).

後処理

  1. customSolvents was removed in vacuo

出典と根拠

ORDレコード
ord-a6b98e8974714a40884ddabce6b2a6c1
出典データセット
uspto-grants-2013_01
特許番号
US08349860B2

関連ノート

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