Hydrochloric Acid → HCID 25227126、化合物

HRID 1802459ノート

反応式

HRID 1802459 の反応式
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH3:28])=[C:9]([NH:11][C:12]2[C:21]3[C:16](=[C:17](Cl)[N:18]=[CH:19][CH:20]=3)[C:15]3[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:14]=3[N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Cl.C([O-])(O)=[O:31].[Na+]>C1COCC1>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH3:28])=[C:9]([NH:11][C:12]2[C:21]3[CH:20]=[CH:19][NH:18][C:17](=[O:31])[C:16]=3[C:15]3[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:14]=3[N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 59436103N-(5-tert-Butyl-2-methylphenyl)-1-chloro-9-fluorobenzo[c]-2,6-naphthyridin-5-amine

生成物 1

HCID 25227126HCID 25227126、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

N-(5-tert-butyl-2-methylphenyl)-1-chloro-9-fluorobenzo[c]-2,6-naphthridin-5-amine (110 mg, 0.28 mmol) was taken up in THF (3.5 mL) and 6 N HCl (3.5 mL) and heated to 85° C. for 2 hr. The reaction was cooled to room temperature, neutralized with saturated NaHCO3 and extracted with EtOAc. The organic layers were dried over Mg2SO4, filtered, and concentrated. Column chromatography on silica gel (100% hexane to 100% EtOAc) provided the title compound.

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layers were dried over Mg2SO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0bbae645fa5c4700a714cda29533945f
出典データセット
uspto-grants-2013_01
特許番号
US08349865B2

反応ノート

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