Triethylamine → HCID 136337086、化合物

HRID 1802504ノート

反応式

HRID 1802504 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:28])[C:9]=1[NH:10][C:11]1[C:20]2[CH:21]=[CH:22][N:23]=[C:24]([O:25][CH2:26][CH3:27])[C:19]=2[C:18]2[C:13](=[CH:14][CH:15]=[N:16][CH:17]=2)[N:12]=1)[C:5]#[N:6].C(N(CC)CC)C.[Cl-].[OH:37][NH3+:38]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5](=[N:38][OH:37])[NH2:6])[CH:7]=[C:8]([Cl:28])[C:9]=1[NH:10][C:11]1[C:20]2[CH:21]=[CH:22][N:23]=[C:24]([O:25][CH2:26][CH3:27])[C:19]=2[C:18]2[C:13](=[CH:14][CH:15]=[N:16][CH:17]=2)[N:12]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 21645Hydroxylamine HClHCID 68424405HCID 68424405、化合物

生成物 1

HCID 136337086HCID 136337086、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of 3,5-dichloro-4-[(10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-yl)amino]benzonitrile (Example 160, Step 1) (200 mg, 0.49 mmol) in ethanol (6 mL) was added triethylamine (0.285 mL, 2.04 mmol) and hydroxyammonium chloride (105 mg, 1.51 mmol). The reaction mixture was heated to 80° C. for 3 h in a sealed tube. After cooling to room temperature, the solid was filtered, washed with ethanol and water and dried under vacuum to afford the title compound.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was filtered
  3. washwashed with ethanol and water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-c8314ed020724a75bc497468f7bdacb9
出典データセット
uspto-grants-2013_01
特許番号
US08349865B2

反応ノート

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