(2-Methoxy-benzyl)-(6-nitro-quinolin-2-yl)-amine → N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine

HRID 1803075

反応式

HRID 1803075 の反応式
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:17]([O-])=O)[CH:13]=2)[N:8]=1>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=2)[N:8]=1

参加物

4

反応物 1

HCID 57647540(2-Methoxy-benzyl)-(6-nitro-quinolin-2-yl)-amine

生成物 1

HCID 43450845N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

(2-Methoxy-benzyl)-(6-nitro-quinolin-2-yl)-amine (0.5 g, 2.0 mmol) were dissolved in ethyl acetate (25 ml). Upon addition of Pd/C (10%, 0.1 g) the reaction mixture was stirred for 45 min at ambient temperature under an atmosphere of hydrogen. Then the catalyst was filtered off, the filter washed with ethyl acetate and the filtrate evaporated. N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine was obtained as a yellow foam (0.40 g, 87%); MS: m/e=280.5 (M+H+).

後処理

  1. filtrationThen the catalyst was filtered off
  2. washthe filter washed with ethyl acetate
  3. customthe filtrate evaporated

出典と根拠

ORDレコード
ord-2fbd740fd08441269def9e08f5e5e17a
出典データセット
uspto-grants-2013_01
特許番号
US08350028B2

関連ノート

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