Methyl iodide → HCID 178493238、化合物
反応式
[I:1][CH3:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([NH:17][C:18]([NH2:20])=[S:19])[CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[N:14][C:13]([CH3:16])=[N:12]1>C(O)C>[IH:1].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([NH:17][C:18]([S:19][CH3:2])=[NH:20])[CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[N:14][C:13]([CH3:16])=[N:12]1参加物
4
反応条件
- 温度
- 70 °C
実験手順
Step F (5): Iodomethane (1.04 mL, 16.67 mmol) was added to a solution of 1-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)thiourea (4.18 g, 15.87 mmol) in absolute ethanol (100 mL). The resulting mixture was heated at 70° C. for 3 h. After cooling to rt, the reaction was concentrated in vacuo. The residual volatiles were removed in high vacuo to afford methyl 3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylcarbamimidothioate, hydroiodide (6.52 g, 16.09 mmol, 101% yield) as a white solid. LC-MS (M+H)+ 278.1.