Sodium borohydride → 1-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol

HRID 1803630ノート

反応式

HRID 1803630 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:16])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1.[BH4-].[Na+]>CO>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([OH:16])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 610568711-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-one

生成物 1

HCID 627174681-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-one (20 g, 92.56 mmol) was dissolved in MeOH (200 mL), and NaBH4 (3.5 g, 92.52 mmol) was slowly added to the solution at 5° C. After the reaction was completed, the solution was quenched with H2O, and the MeOH was evaporated. The residue was extracted with EtOAc and the organic layer was washed with brine, dried over MgSO4, and evaporated to give the 1-(furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol as yellow oil: 20 g (crude yield: 98%)

後処理

  1. customthe solution was quenched with H2O
  2. customthe MeOH was evaporated
  3. extractionThe residue was extracted with EtOAc
  4. washthe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. customevaporated

出典と根拠

ORDレコード
ord-cfc50fc9df124071abe328827218eeae
出典データセット
uspto-grants-2013_01
特許番号
US08350090B1

反応ノート

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