Sodium borohydride → HCID 71170040、化合物
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:22])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=1.[BH4-].[Na+]>CO>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([OH:22])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=1参加物
4
実験手順
1-(Furan-2-yl)-2-(3-benzyloxyphenyl)ethan-1-one (4 kg, 13.69 mol) was dissolved in MeOH (35 L), and NaBH4 (520 g, 13.75 mol) was slowly added to the solution at 5° C. After the reaction was completed, the solution was quenched with H2O, and the MeOH was evaporated. The residue was extracted with EtOAc and the organic layer was washed with brine, dried over MgSO4, and evaporated to give the 1-(furan-2-yl)-2-(3-benzyloxyphenyl)ethan-1-ol as yellow oil: 3.97 kg (crude yield: 98%)