Sodium Hydroxide → 2-Methyl-4-(4-methylpiperazin-1-yl)benzoic acid
反応式
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:6][C:5]=1[CH3:17].[OH-].[Na+]>>[CH3:17][C:5]1[CH:6]=[C:7]([N:10]2[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]2)[CH:8]=[CH:9][C:4]=1[C:3]([OH:18])=[O:2]参加物
3
反応条件
- 温度
- 40 °C
実験手順
To a solution of 2-methyl-4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester (660 mg, 2.66 mmol) in MeOh (4 ml), 2M NaOH (4 ml, 8 mmol) was added. The reaction was heated for 3 hours at 40° C. until HPLC revealed the disappearance of the starting-material. The solvent was removed under reduced pressure and the solution was diluted with water and neutralized to pH 7 with aqueous 25% HCl. The precipitate was filtrated and washed with Et2O to afford the desired final compound as with solid (400 mg, 64%).
後処理
- custom