Hydrogen Bromide → 2-Bromo-1-phenyl-2-pyrid-4-ylethanone

HRID 1803901ノート

反応式

HRID 1803901 の反応式
[C:1]1([C:7](=[O:15])[CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BrH:16].BrBr>C(O)(=O)C>[Br:16][CH:8]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:15]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 2871041-Phenyl-2-(4-pyridinyl)ethanone

生成物 1

HCID 134660102-Bromo-1-phenyl-2-pyrid-4-ylethanone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒3 回

反応条件

温度
60 °C

実験手順

To a solution of 36 g (182 mmol) of 1-phenyl-2-pyrid-4-ylethanone in 350 mL of acetic acid are successively added at room temperature 28 ml (210 mmol) of a solution containing 30% by weight of hydrobromic acid in acetic acid and 10.1 ml (197 mmol) of bromine dissolved in 50 mL of acetic acid. The solution is heated at 60° C. for one hour and then cooled. The product is precipitated by adding diethyl ether, and 63 g of a yellow solid are isolated after drying.

後処理

  1. temperaturecooled
  2. customThe product is precipitated
  3. additionby adding diethyl ether, and 63 g of a yellow solid
  4. customare isolated
  5. customafter drying

出典と根拠

ORDレコード
ord-d2eff27045ce408dbfeac5cecbe36e99
出典データセット
uspto-grants-2013_01
特許番号
US08354405B2

反応ノート

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