(R)-4-Methyloxazolidin-2-one → methyl (R)-3-fluoro-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate

HRID 1804028

反応式

HRID 1804028 の反応式
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[F:12].[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[F:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:15]1[C@H:14]([CH3:13])[CH2:18][O:17][C:16]1=[O:19])[C:6]([O:8][CH3:9])=[O:7]

参加物

3

反応物 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 21951878Methyl 4-bromo-3-fluorobenzoate

生成物 1

HCID 58484559methyl (R)-3-fluoro-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate収率 92%

実験手順

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 4-bromo-3-fluorobenzoate (1.2 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1.2 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12
  3. customdescribed in Preparation Example 25

出典と根拠

ORDレコード
ord-dcd11aec23964959813ce4c5b17fd4e6
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

関連ノート

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