Cl.[CH:2]1([C:5]2[CH:6]=[C:7]([CH3:17])[C:8]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[N:9][CH:10]=2)[CH2:4][CH2:3]1.C(OCC)(=O)C.[OH-].[Na+].[Cl-].[Na+]>O>[CH:2]1([C:5]2[CH:6]=[C:7]([CH3:17])[C:8]([N:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)=[N:9][CH:10]=2)[CH2:4][CH2:3]1To 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride described in Preparation Example 49 was added ethyl acetate (50 mL), 1N aqueous sodium hydroxide solution (10 mL) was added under cooling and the mixture was stirred. To the reaction mixture were added sodium chloride and water under cooling, and the mixture was extracted twice with ethyl acetate. The organic layer was dried over sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (1.43 g).
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