4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyrazin-2-yl)piperazin-1-yl]methanone

HRID 1804055

反応式

HRID 1804055 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH3:13][C:14]1[C:15]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:16][CH:17]=[C:18]([CH3:20])[N:19]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:15]3[C:14]([CH3:13])=[N:19][C:18]([CH3:20])=[CH:17][N:16]=3)[CH2:22][CH2:23]2)=[O:7])=[C:4]([F:11])[CH:3]=1

参加物

3

反応物 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 67381341(3,5-Dimethylpyrazin-2-yl)piperazine hydrochloride

生成物 1

HCID 58484696(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyrazin-2-yl)piperazin-1-yl]methanone収率 69.9%

実験手順

By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-fluorobenzoyl chloride (1.1 g) and 1-(3,5-dimethylpyrazin-2-yl)piperazine hydrochloride (915 mg) described in Preparation Example 59, the title compound (1.1 g) was obtained.

後処理

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 8
  3. customdescribed in Preparation Example 59

出典と根拠

ORDレコード
ord-4cd6e7e1f65a44afb88ec664acedf589
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

関連ノート

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