化工社化工社 化学情報印刷レポート · 研究参考用
N-Acetylimidazolidinone → 1-Acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Acetylimidazolidinone | HCID 79350 | — |
| 反応物 | (2-Bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484730 | — |
| 生成物 | 1-Acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one | HCID 58484683 | 48.6% |
反応手順
By reaction and treatment in the same manner as in Preparation Example 12 and using (2-bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (408.7 mg) described in Preparation Example 119 and 1-acetyl-2-imidazolidinone (128 mg), the title compound (221.5 mg) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08354401B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-d21bd3ebc0454c659f701522f20f091a |
| 出典メモ | uspto-grants-2013_01 |