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HRID 1804085作成日：2026年10月27日

6-Fluoro-4-methylpyridine-3-carboxylic acid → [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone

https://huagongshe.com/reaction/1804085

反応式

関与物質

役割名称HCID仕込み量
反応物6-Fluoro-4-methylpyridine-3-carboxylic acidHCID 46739274—
反応物1-(3,5-Dicyclopropylpyridin-2-yl)piperazineHCID 58484701—
生成物[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanoneHCID 5848458385.3%

反応手順

By reaction and treatment in the same manner as in Preparation Example 60 and using 6-fluoro-4-methylnicotinic acid (600 mg) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (922 mg) described in Preparation Example 62, the title compound (1.23 g) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08354401B2
出典データセットuspto-grants-2013_01
ORD IDord-32fe52f8662941c7a606f93d7c255c3d
出典メモuspto-grants-2013_01