Sodium Hydroxide → 1-(3,5,6-Trimethylpyridin-2-yl)piperazine
反応式
Cl.[CH3:2][C:3]1[C:4]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:5][C:6]([CH3:10])=[C:7]([CH3:9])[CH:8]=1.[OH-].[Na+]>C(OCC)(=O)C>[CH3:2][C:3]1[C:4]([N:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)=[N:5][C:6]([CH3:10])=[C:7]([CH3:9])[CH:8]=1参加物
4
実験手順
To 1-(3,5,6-trimethylpyridin-2-yl)piperazine hydrochloride described in Preparation Example 52 were added ethyl acetate and 1N aqueous sodium hydroxide solution, and the mixture was extracted with ethyl acetate and washed with saturated brine. The solvent was evaporated to give 1-(3,5,6-trimethylpyridin-2-yl)piperazine (470 mg). By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (407 mg) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (470 mg), the title compound (620 mg) was obtained.