Sodium Hydroxide → 4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid

HRID 1804123ノート

反応式

HRID 1804123 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([N:12]2[CH2:16][CH2:15][CH2:14][S:13]2(=[O:18])=[O:17])[CH:3]=1.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N:12]2[CH2:16][CH2:15][CH2:14][S:13]2(=[O:17])=[O:18])[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58484624Methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate

生成物 1

HCID 549330084-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid収率 98.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

To methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate (5.57 g) described in Preparation Example 116 were added ethanol (43 mL) and 1N aqueous sodium hydroxide solution (21.7 mL) and the mixture was stirred at 60° C. for 40 min. Ethanol was evaporated and the mixture was neutralized with water and 1N hydrochloric acid under ice-cooling and the mixture was stirred. The precipitated crystal were collected by filtration to give the title compound (5.25 g).

後処理

  1. customEthanol was evaporated
  2. temperaturecooling
  3. stirringthe mixture was stirred
  4. filtrationThe precipitated crystal were collected by filtration

出典と根拠

ORDレコード
ord-9e7de342340d441ca09e6caac18c3265
出典データセット
uspto-grants-2013_01
特許番号
US08354401B2

反応ノート

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