Methyl iodide → (R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-methoxymethyloxazolidin-2-one

反応式

[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:22]=[CH:23][C:24]([N:27]5[C@H:31]([CH2:32][OH:33])[CH2:30][O:29][C:28]5=[O:34])=[N:25][CH:26]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:35]I>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:22]=[CH:23][C:24]([N:27]5[C@H:31]([CH2:32][O:33][CH3:35])[CH2:30][O:29][C:28]5=[O:34])=[N:25][CH:26]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:2][CH2:3]1

参加物

反応物 2

HCID 6328Methyl iodide

HCID 58484584(R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one

生成物 1

HCID 58484834(R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-methoxymethyloxazolidin-2-one

実験手順

By reaction and treatment in the same manner as in Example 73 and using (R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one (310 mg) described in Example 252 and methyl iodide (50 μL), the title compound (85 mg) was obtained.

後処理

customBy reaction and treatment in the same manner as in Example 73

出典と根拠

ORDレコード: ord-72b11eb38a1d440eba293c3c3a5e6e91
出典データセット: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08354401B2

反応ノート

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