Tert-butyl 1-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate → 1-(4-(5-(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

HRID 1804525ノート

反応式

HRID 1804525 の反応式
[C:1]1([C:7]2[CH:8]=[C:9]([C:16]3[O:20][N:19]=[C:18]([C:21]4[CH:38]=[CH:37][C:24]([CH2:25][N:26]5[CH2:29][CH:28]([C:30]([O:32]C(C)(C)C)=[O:31])[CH2:27]5)=[CH:23][CH:22]=4)[N:17]=3)[S:10][C:11]=2[C:12]([F:15])([F:14])[F:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>FC(F)(F)C(O)=O.CO>[C:1]1([C:7]2[CH:8]=[C:9]([C:16]3[O:20][N:19]=[C:18]([C:21]4[CH:38]=[CH:37][C:24]([CH2:25][N:26]5[CH2:27][CH:28]([C:30]([OH:32])=[O:31])[CH2:29]5)=[CH:23][CH:22]=4)[N:17]=3)[S:10][C:11]=2[C:12]([F:13])([F:15])[F:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 1

HCID 66678166Tert-butyl 1-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

生成物 1

HCID 101742551-(4-(5-(4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid収率 74%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of tert-butyl 1-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate (518 mg, 0.956 mmol) in trifluoroacetic acid (15 mL) was allowed to stand at room temperature for 1.5 h. The volatiles were removed under reduced pressure, and the residue was co-evaporated from ethyl acetate/hexanes. (2×10 mL). The residue was suspended in water (10 mL) and the pH was adjusted to ˜11 with 1N aqueous sodium hydroxide. To this solution was added sufficient 1N aqueous hydrochloric acid to adjust the pH ˜4.5. The resulting suspension was stirred at room temperature overnight. The white suspension was filtered through a medium porosity sintered glass filter, and the filter cake was washed thoroughly with water. The solid was dried, the white powder was suspended in methanol, and the suspension was sonicated until it was uniform. The methanol was removed under reduced pressure, and the procedure was repeated twice more to afford a white solid that was stirred as a suspension in methanol (−30 mL) overnight. Vacuum filtration and drying afforded 1-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-azetidine-3-carboxylic acid (345 mg, 0.707 mmol, 74% yield) as a white powder. HPLC ret. time=3.45 min. (YMC Combi S-5 4.6×50 mm ODS column) eluting with 10-90% aqueous methanol+0.2% phosphoric acid over a 4 minute gradient. MS: (M+H)=486.12. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.23 (s, 3H), 3.39-3.45 (m, 2H), 3.64 (s, 2H), 7.50 (d, J=8.28 Hz, 2H), 7.58 (m, 5H), 8.02 (d, J=8.28 Hz, 2H), and 8.26 (d, J=1.25 Hz, 1H). Elemental Analysis: Calc. for C24H18N3O3SF3.0.1H2O: C 59.22; H, 3.76; N, 8.63, S 6.59, F 11.71. Found: C24H18N3O3SF3-0.1H2O: C 59.06; H, 3.45; N, 8.60, S 6.61, F 11.42; KF (Found)=0.25% water.

後処理

  1. customThe volatiles were removed under reduced pressure
  2. additionTo this solution was added sufficient 1N aqueous hydrochloric acid
  3. filtrationThe white suspension was filtered through a medium porosity sintered glass
  4. filtrationfilter
  5. washthe filter cake was washed thoroughly with water
  6. customThe solid was dried
  7. customthe suspension was sonicated until it
  8. customThe methanol was removed under reduced pressure
  9. customto afford a white solid
  10. filtrationVacuum filtration
  11. customdrying

出典と根拠

ORDレコード
ord-8fe7fd6db9aa481783eacbdfec9a7baa
出典データセット
uspto-grants-2013_01
特許番号
US08354398B2

反応ノート

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