Water → HCID 57698624、化合物

HRID 1804546ノート

反応式

HRID 1804546 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[C:12]([NH:16][C:17](=[O:22])[O:18][CH2:19][CH2:20]Cl)[CH:13]=[CH:14][CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+].O>O1CCCC1>[O:22]=[C:17]1[N:16]([C:12]2[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=2)[CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:20][CH2:19][O:18]1

参加物

5

反応物 3

HCID 962WaterHCID 23665647Potassium tert-butoxideHCID 57698618HCID 57698618、化合物

生成物 1

HCID 57698624HCID 57698624、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.20 g (3.65 mmol) 2-chloro-ethyl [3-(tert-butoxycarbonylamino-methyl)-phenyl]-carbamate and 0.850 g (7.58 mmol) potassium tert.butoxide are placed at 0° C. in 30 ml of tetrahydrofuran and the mixture is stirred for 3 hours at ambient temperature. Then the reaction mixture is added to water and extracted with dichloromethane. The organic phase is dried and evaporated to dryness. The residue is purified by chromatography.

後処理

  1. extractionextracted with dichloromethane
  2. customThe organic phase is dried
  3. customevaporated to dryness
  4. customThe residue is purified by chromatography

出典と根拠

ORDレコード
ord-20eaf5ef5883475ca85bc90d7be04b12
出典データセット
uspto-grants-2013_01
特許番号
US08354418B2

反応ノート

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