Trifluoroacetic acid → 2-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

HRID 1804565ノート

反応式

HRID 1804565 の反応式
[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:6][N:5]=1)([CH3:3])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH2:11])=[N:6][N:5]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57637115Tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate

生成物 1

HCID 242544832-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4.00 g (15.67 mmol) tert-butyl [2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 20 ml trifluoroacetic acid are stirred in 200 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.

後処理

  1. customThen the mixture is evaporated down
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-e0ab4ef7536c4e8c862400cbe78f2ecb
出典データセット
uspto-grants-2013_01
特許番号
US08354418B2

反応ノート

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