1-(2,3-Dihydro-5-nitro-1H-pyrrolo(2,3-b)pyridin-1-yl)ethanone → HCID 66845730、化合物
反応式
[C:1]([N:4]1[C:8]2=[N:9][CH:10]=[C:11]([N+:13]([O-])=O)[CH:12]=[C:7]2[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([N:4]1[C:8]2=[N:9][CH:10]=[C:11]([NH2:13])[CH:12]=[C:7]2[CH2:6][CH2:5]1)(=[O:3])[CH3:2]参加物
5
実験手順
A suspension of 0.43 g (2.08 mmol) of 1-acetyl-2,3-dihydro-5-nitro-1H-pyrrolo[2,3-b]pyridine (Tetrahedron Lett. 1987, 1589) and 0.044 g of 10% palladium-on-charcoal in 15 mL of ethanol is stirred vigorously for 6 hours at room temperature and under 5 atmospheres of hydrogen. After this time, the suspension is filtered through Celite and the filtrate is concentrated under reduced pressure to give 0.24 g of the expected product in the form of a solid.
後処理
- filtrationAfter this time, the suspension is filtered through Celite
- concentrationthe filtrate is concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-c1d594c5907041dcb4d7bebf8c60051c
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08354425B2
反応ノート
読み込み中…