HCID 67361944、化合物 → HCID 59152645、化合物

HRID 1804769ノート

反応式

HRID 1804769 の反応式
Cl.[CH3:2][C@@H:3]1[C@@H:8]([OH:9])[CH2:7][CH2:6][N:5]([CH2:10][CH2:11][C:12]23[CH2:19][CH2:18][CH:15]([CH2:16][CH2:17]2)[NH:14][O:13]3)[CH2:4]1>CO.[Pd]>[NH2:14][CH:15]1[CH2:16][CH2:17][C:12]([CH2:11][CH2:10][N:5]2[CH2:6][CH2:7][C@H:8]([OH:9])[C@@H:3]([CH3:2])[CH2:4]2)([OH:13])[CH2:19][CH2:18]1

参加物

4

反応物 1

HCID 67361944HCID 67361944、化合物

生成物 1

HCID 59152645HCID 59152645、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒2 回

実験手順

10% Pd—C (240 mg) is placed into a round-bottom flask under an argon atmosphere and covered with methanol. A solution of (3S,4S)-3-Methyl-1-[2-(2-oxa-3-aza-bicyclo[2.2.2]oct-1-yl)-ethyl]-piperidin-4-ol (13) (584 mg, 2.3 mmol) in 20 ml of methanol is added and the mixture is hydrogenated for 2 h at room temperature. Then the mixture is filtrated over celite and evaporated under reduced pressure. The product was used in the next step without further purification.

後処理

  1. filtrationThen the mixture is filtrated over celite
  2. customevaporated under reduced pressure
  3. customThe product was used in the next step without further purification

出典と根拠

ORDレコード
ord-a4009fd2c65949e9b785aee14017b0ef
出典データセット
uspto-grants-2013_01
特許番号
US08354431B2

反応ノート

読み込み中…