Ethyl Bromide → 6-Ethoxy-benzofuran-3-carboxylic acid ethyl ester

HRID 1804789ノート

反応式

HRID 1804789 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:10]2[CH:11]=[CH:12][C:13]([OH:15])=[CH:14][C:9]=2[O:8][CH:7]=1)=[O:5])[CH3:2].Br[CH2:17][CH3:18].C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[C:10]2[CH:11]=[CH:12][C:13]([O:15][CH2:17][CH3:18])=[CH:14][C:9]=2[O:8][CH:7]=1)=[O:5])[CH3:2]

参加物

5

反応物 3

HCID 6332Ethyl BromideHCID 10796Cesium carbonateHCID 59152646Ethyl 6-hydroxybenzofuran-3-carboxylate

生成物 1

HCID 673618076-Ethoxy-benzofuran-3-carboxylic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

6-Hydroxy-benzofuran-3-carboxylic acid ethyl ester (26) (8 g, 39 mmol) is dissolved in 80 ml of DMF and after addition of bromoethane (5.8 ml, 78 mmol) and Cs2CO3 (15.2 g, 46.6 mmol) the mixture is stirred for 2 h at 100° C. After evaporation of the mixture at high vacuum, the residue is dissolved in ethyl acetate, washed with water and with brine, dried over sodium sulfate and evaporated under reduced pressure. The yellow solid is used in the next step without further purification.

後処理

  1. customAfter evaporation of the mixture at high vacuum
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. washwashed with water and with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated under reduced pressure
  6. customThe yellow solid is used in the next step without further purification

出典と根拠

ORDレコード
ord-57a15d263bef433da12b9270a65e82a7
出典データセット
uspto-grants-2013_01
特許番号
US08354431B2

反応ノート

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