Isopropanol → 2-Isopropoxypyrimidine
反応式
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(NC(C)C)(C)C.[CH:15]([OH:18])([CH3:17])[CH3:16]>>[CH:15]([O:18][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1)([CH3:17])[CH3:16]参加物
4
反応条件
- 温度
- 130 °C
実験手順
A 2-chloropyrimidine was dissolved in isopropyl alcohol to which was added diisopropylamine. The reaction was heated in a sealed tube for ten days at 130° C. The cooled reaction mixture was concentrated, and the product purified via silica gel column chromatography to yield the 2-isopropoxypyrimidine.
後処理
- customThe cooled reaction mixture
- concentrationwas concentrated
- customthe product purified via silica gel column chromatography
出典と根拠
- ORDレコード
- ord-5eeae7a57a0340a0ac9a97edec8fd5c5
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741328B2
反応ノート
読み込み中…