Isopropanol → 2-Isopropoxypyrimidine

HRID 18048

反応式

HRID 18048 の反応式
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(NC(C)C)(C)C.[CH:15]([OH:18])([CH3:17])[CH3:16]>>[CH:15]([O:18][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1)([CH3:17])[CH3:16]

参加物

4

反応物 3

HCID 3776IsopropanolHCID 7912DiisopropylamineHCID 744042-Chloropyrimidine

生成物 1

HCID 221388532-Isopropoxypyrimidine

反応条件

温度
130 °C

実験手順

A 2-chloropyrimidine was dissolved in isopropyl alcohol to which was added diisopropylamine. The reaction was heated in a sealed tube for ten days at 130° C. The cooled reaction mixture was concentrated, and the product purified via silica gel column chromatography to yield the 2-isopropoxypyrimidine.

後処理

  1. customThe cooled reaction mixture
  2. concentrationwas concentrated
  3. customthe product purified via silica gel column chromatography

出典と根拠

ORDレコード
ord-5eeae7a57a0340a0ac9a97edec8fd5c5
出典データセット
uspto-grants-2010_06
特許番号
US07741328B2

関連ノート

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