Ethylene Glycol → 3-(2-Hydroxyethyl)indolin-2-one

HRID 1805024ノート

反応式

HRID 1805024 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH2:11](O)[CH2:12][OH:13]>[Ni]>[OH:13][CH2:12][CH2:11][CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10]

参加物

4

反応物 2

HCID 174Ethylene GlycolHCID 321710Oxindole

生成物 1

HCID 108992203-(2-Hydroxyethyl)indolin-2-one収率 70%

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

A stifling mixture of oxindole (5.7 g, 43 mmol) and Raney nickel (10 g) in ethane-1,2-diol (100 mL) was heated in an autoclave. After the reaction was complete, the mixture was filtered and the excess of diol was removed under vacuum. The residual oil was triturated with hexane to give 3-(2-hydroxy-ethyl)-1,3-dihydro-indol-2-one as a colorless crystalline solid (4.6 g, 70%).

後処理

  1. temperaturewas heated in an autoclave
  2. filtrationthe mixture was filtered
  3. customthe excess of diol was removed under vacuum
  4. customThe residual oil was triturated with hexane

出典と根拠

ORDレコード
ord-3b7a6c761fbe4da988cbdd08018a260f
出典データセット
uspto-grants-2013_01
特許番号
US08354427B2

反応ノート

読み込み中…