Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate → Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

HRID 1805249

反応式

HRID 1805249 の反応式
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([O:14][CH3:15])=[O:13])=[CH:4][N:3]=1.[CH3:16][O-:17].[Na+]>CO>[CH3:16][O:17][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([O:14][CH3:15])=[O:13])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 3696469Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylateHCID 10942334Sodium Methoxide

生成物 1

HCID 22831728Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
110 °C

実験手順

Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (1128 mg) was dissolved in MeOH (23 ml) before addition of sodium methoxide (380 mg), the reaction mixture was stirred for 2 hours in a sealed tube at 110° C. The solvent was evaporated, the product dissolved in ethyl acetate and washed with water, the organics were dried over Na2SO4, and concentrated in vacuo to afford title compound as a colourless oil. MS (ISP) 237.0 ([M+H]+)

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe product dissolved in ethyl acetate
  3. washwashed with water
  4. dry with materialthe organics were dried over Na2SO4
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-b44112ae04204f93bc669ab934edfad4
出典データセット
uspto-grants-2013_01
特許番号
US08354441B2

関連ノート

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