Potassium Carbonate → (1R,2S)-2-(4-chlorophenyl)-1'-(1-trityl-1 H-imidazol-4-yl)spiro[cyclopropane-1,3'-indolin]-2'-one

反応式

I[C:2]1[N:3]=[CH:4][N:5]([C:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=1.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C@@H:33]2[C@:35]3([C:43]4[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=4)[NH:37][C:36]3=[O:44])[CH2:34]2)=[CH:29][CH:28]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)CCN>C(#N)C.[Cu]I>[Cl:26][C:27]1[CH:28]=[CH:29][C:30]([C@H:33]2[C@@:35]3([C:43]4[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=4)[N:37]([C:2]4[N:3]=[CH:4][N:5]([C:7]([C:8]5[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=5)([C:20]5[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=5)[C:14]5[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=5)[CH:6]=4)[C:36]3=[O:44])[CH2:34]2)=[CH:31][CH:32]=1