Sodium Dithionite → N'-(3-benzyl-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-2-yl)-N,N-dimethylmethanimidamide
反応式
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([N+]([O-])=O)=[C:11](/[CH:18]=[CH:19]/[N:20](C)C)[N:10]=[C:9]1/[N:23]=[CH:24]/[N:25]([CH3:27])[CH3:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-]S(S([O-])=O)=O.[Na+].[Na+]>C1COCC1>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[NH:20][CH:19]=[CH:18][C:11]=2[N:10]=[C:9]1/[N:23]=[CH:24]/[N:25]([CH3:26])[CH3:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
To a mixture of (E)-N′-(1-benzyl-4-((E)-2-(dimethylamino)vinyl)-5-nitro-6-oxo-1,6-dihydropyrimidin-2-yl)-N,N-dimethylformimidamide (43.0 g, 0.12 mol) in THF (151 mL) was added an aqueous saturated solution of Na2S2O4 and stirred at room temperature overnight. Upon completion of the reaction, the solid was filtered and washed with THF to afford the product (21.2 g, 62% yield) which was used in the next step without further purification.