Methane → HCID 178518411、化合物

HRID 1805997ノート

反応式

HRID 1805997 の反応式
ClC1N=[C:4](NC2C=C(C=CC=2)C(O)=O)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2N=1.[NH2:21][C:22]([NH2:24])=[O:23].C.[OH-:26].[Na+]>>[N:21]1[C:6]2[CH:8]=[CH:9][S:10][C:5]=2[C:4]([OH:26])=[N:24][C:22]=1[OH:23]

参加物

5

反応物 4

HCID 297MethaneHCID 1176UreaHCID 14798Sodium HydroxideHCID 576001073-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)benzoic acid

生成物 1

HCID 178518411HCID 178518411、化合物収率 75%

実験手順

10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.

後処理

  1. temperatureAfter cooling
  2. filtrationIt is filtered
  3. temperaturethe filtrate is cooled
  4. customThe precipitate formed
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-af2a06948cb2485f8b3359544a4488d2
出典データセット
uspto-grants-2013_01
特許番号
US08354531B2

反応ノート

読み込み中…