Ammonia → 4-Methyl-sulfonylpyridine
反応式
CS([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)(=O)=O.[CH3:11]SC1C=CN=CC=1.OO.N.[S:22]([O-:25])(O)=[O:23].[Na+]>[O-][W]([O-])(=O)=O.[Na+].[Na+].C(O)(=O)C.O>[CH3:11][C:5]1[CH:6]=[CH:7][NH:8][C:9](=[S:22](=[O:25])=[O:23])[CH:10]=1参加物
9
実験手順
4-Methylsulfonylpyridine may be prepared by carrying out the procedure as described in Example 20, starting with 14 g of sodium tungstate, 4 cm3 of water, 0.05 cm3 of 100% acetic acid, 3.3 g of 4-methylsulfanyl-pyridine, 6.5 cm3 of 30% hydrogen peroxide and then 0.25 cm3 of 32% aqueous ammonia and 1 cm3 of 37.5% aqueous solution of sodium hydrogen sulfite. The crude oil obtained is crystallized with 10 cm3 of diisopropyl ether, the crystals are filtered, drained and dried under reduced pressure (2.7 kPa). 2.6 g of 4-methyl-sulfonylpyridine are obtained in the form of white crystals.
後処理
- customThe crude oil obtained
- customis crystallized with 10 cm3 of diisopropyl ether
- filtrationthe crystals are filtered
- customdried under reduced pressure (2.7 kPa)
出典と根拠
- ORDレコード
- ord-0849b5bd46324f2ca8a266329f580a42
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741316B2
反応ノート
読み込み中…
