Sodium Sulfite → 3,3,4-Trimethylpentanal

HRID 1806851ノート

反応式

HRID 1806851 の反応式
[CH3:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[CH2:3][CH2:4][OH:5].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[O-]S([O-])=O.[Na+].[Na+]>ClCCl>[CH3:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[CH2:3][CH:4]=[O:5]

参加物

5

反応物 3

HCID 24437Sodium SulfiteHCID 159087TriacetoxyperiodinaneHCID 124253343,3,4-Trimethylpentan-1-ol

生成物 1

HCID 124253353,3,4-Trimethylpentanal収率 21%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Step C To a solution of 3,3,4-trimethyl-pentan-1-ol (5.4 g, 41 mmol) in dichloromethane (100 mL) was added Dess-Martin periodinane (22 g 52 mmol) The reaction mixture was stirred at room temperature for 3 h. Aqueous Na2SO3 solution was added to quench the reaction. The organic layers were separated, washed with saturated NaHCO3, brine, dried over MgSO4, and concentrated. The residue was purified by chromatography (EtOAc:hexanes=1:30) to give 3,3,4-trimethyl-pentanal as a colorless oil (Yield: 1.1 g, 21%).

後処理

  1. customto quench
  2. customthe reaction
  3. customThe organic layers were separated
  4. washwashed with saturated NaHCO3, brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated
  7. customThe residue was purified by chromatography (EtOAc:hexanes=1:30)

出典と根拠

ORDレコード
ord-04793b282781441ba373943a0ab4286c
出典データセット
uspto-grants-2013_01
特許番号
US08354444B2

反応ノート

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