Methyl 4-nitro-2-(trifluoromethyl)benzoate → Methyl 4-amino-2-(trifluoromethyl)benzoate

HRID 1807194ノート

反応式

HRID 1807194 の反応式
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][C:5]=1[C:13]([F:16])([F:15])[F:14]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][C:5]=1[C:13]([F:14])([F:16])[F:15]

参加物

4

反応物 1

HCID 46311176Methyl 4-nitro-2-(trifluoromethyl)benzoate

生成物 1

HCID 46311081Methyl 4-amino-2-(trifluoromethyl)benzoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 4-nitro-2-trifluoromethyl benzoic acid methyl ester (Aldrich, 700 mg, 3.24 mmol) in ethyl acetate (50 mL) was treated with 10% Pd/C (50 mg) and hydrogenated at 1 atmosphere for 3 hrs. The mixture was filtered and concentrated to give a light yellow solid which was directly used for the next step.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customto give a light yellow solid which

出典と根拠

ORDレコード
ord-583aeee62d46420193edc2379ab2126f
出典データセット
uspto-grants-2013_01
特許番号
US08354444B2

反応ノート

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