Methyl 2-ethoxy-4-nitrobenzoate → Methyl 4-amino-2-ethoxybenzoate

HRID 1807272

反応式

HRID 1807272 の反応式
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7])[CH3:2].[H][H]>[Pd].CO>[NH2:14][C:12]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:3][CH2:1][CH3:2])[CH:13]=1

参加物

5

反応物 2

HCID 9964566Methyl 2-ethoxy-4-nitrobenzoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 67368855Methyl 4-amino-2-ethoxybenzoate収率 94.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of methyl 2-ethoxy-4-nitrobenzoate (2.038 g, 9.05 mmol) and palladium on carbon (583 mg, 10 wt %, Aldrich) in methanol (62 ml) was reacted with hydrogen at 40 psi for 18 hrs on the PARR shaker. It was filtered through celite and washed with methanol under N2 and the filtrate was concentrated to give methyl 4-amino-2-ethoxybenzoate (1.672 g, 94%) as a light brown solid.

後処理

  1. filtrationIt was filtered through celite
  2. washwashed with methanol under N2
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-9acd94964bc04e788752929f301a7dac
出典データセット
uspto-grants-2013_01
特許番号
US08354444B2

関連ノート

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