2-Aminothiazole → 4-Acetylamino-naphthalene-1-sulfonic acid thiazol-2-ylamide

HRID 1807552

反応式

HRID 1807552 の反応式
[C:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([S:15](Cl)(=[O:17])=[O:16])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[NH2:19][C:20]1[S:21][CH:22]=[CH:23][N:24]=1>N1C=CC=CC=1>[S:21]1[CH:22]=[CH:23][N:24]=[C:20]1[NH:19][S:15]([C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:6][CH:7]=1)(=[O:17])=[O:16]

参加物

4

反応物 2

HCID 21552-AminothiazoleHCID 40255964-acetamidonaphthalene-1-sulfonyl Chloride

生成物 1

HCID 595967274-Acetylamino-naphthalene-1-sulfonic acid thiazol-2-ylamide収率 57.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 4-acetamidonaphthalene-1-sulfonyl chloride (3.69 g, 2.42 mmol) and pyridine (2 ml) was added 2-aminothiazole (0.24 g, 2.42 mmol). This mixture was stirred at RT for 72 h. Purification via silica gel chromatography (first using 2% MeOH in CH2Cl2 to wash out remaining amine, then using 8% MeOH in CH2Cl2) gave N-[4-(thiazol-2-ylsulfamoyl)-naphthalen-1-yl]-acetamide (0.48 g, 57%). LC/MS (10-99% CH3CN), M/Z: M+1 obs=348.10; tR=1.78 min.

後処理

  1. customPurification via silica gel chromatography (
  2. washto wash

出典と根拠

ORDレコード
ord-132afd8db6cc48adbc0dff609c01dc39
出典データセット
uspto-grants-2013_01
特許番号
US08357702B2

関連ノート

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