2-Methyl 1-(phenylmethyl) (2S,4R)-4-(dimethylamino)-1,2-pyrrolidinedicarboxylate → (2S,4R)-Methyl 4-(dimethylamino)pyrrolidine-2-carboxylate
反応式
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([N:10]([CH3:12])[CH3:11])[CH2:7][N:6]1C(OCC1C=CC=CC=1)=O)=[O:4].[H][H]>[Pd].CO>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([N:10]([CH3:11])[CH3:12])[CH2:7][NH:6]1)=[O:4]参加物
5
実験手順
A mixture of (2S,4R)-4-dimethylamino-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (Stage B.2, 420 mg), 10% palladium on carbon (80 mg) and MeOH (10 mL) was stirred for 16 h under an atm. of hydrogen. Filtration and evaporation gave the title compound which was used without purification in the following steps.
後処理
- filtrationFiltration and evaporation
出典と根拠
- ORDレコード
- ord-d03c55539ad04d83931d3f7c2dac8151
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08357707B2
反応ノート
読み込み中…