HCID 86638587、化合物 → 2-(4-((4-(3-Aminophenylsulfonyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

HRID 1807811ノート

反応式

HRID 1807811 の反応式
[F:1][C:2]([F:35])([F:34])[C:3]([C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([N+:31]([O-])=O)[CH:26]=3)(=[O:24])=[O:23])[CH2:18][CH2:17]2)=[CH:11][CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5]>[Pd].C(OCC)(=O)C>[NH2:31][C:27]1[CH:26]=[C:25]([S:22]([N:19]2[CH2:18][CH2:17][N:16]([CH2:15][C:12]3[CH:11]=[CH:10][C:9]([C:3]([OH:8])([C:2]([F:35])([F:34])[F:1])[C:4]([F:5])([F:6])[F:7])=[CH:14][CH:13]=3)[CH2:21][CH2:20]2)(=[O:23])=[O:24])[CH:30]=[CH:29][CH:28]=1

参加物

4

反応物 1

HCID 86638587HCID 86638587、化合物

生成物 1

HCID 866385882-(4-((4-(3-Aminophenylsulfonyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol収率 115.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

1,1,1,3,3,3-Hexafluoro-2-(4-((4-(3-nitrophenylsulfonyl)piperazin-1-yl)methyl)phenyl)propan-2-ol (1.660 mmol, 875.3 mg) and palladium on carbon were combined in ethyl acetate (20 mL). The reaction mixture was hydrogenated at 2 bar pressure for 1 hour. The reaction mixture was filtered through dicalite and concentrated under vacuum to afford the title compound (950.5 mg).

後処理

  1. filtrationThe reaction mixture was filtered through dicalite
  2. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-c2449ea2a85044ffb759e48581fe0b31
出典データセット
uspto-grants-2013_01
特許番号
US08357679B2

反応ノート

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