Trifluoroacetic acid → HCID 59483827、化合物

HRID 1808388ノート

反応式

HRID 1808388 の反応式
C(O)(C(F)(F)F)=O.[N:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:42][CH2:41][C:17]3([CH2:22][CH2:21][N:20]([C:23]([C:25]4[N:26]=[C:27]5[CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29][N:28]5[CH:40]=4)=[O:24])[CH2:19][CH2:18]3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1>C(Cl)Cl>[N:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:42][CH2:41][C:17]3([CH2:18][CH2:19][N:20]([C:23]([C:25]4[N:26]=[C:27]5[CH2:32][NH:31][CH2:30][CH2:29][N:28]5[CH:40]=4)=[O:24])[CH2:21][CH2:22]3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59483777HCID 59483777、化合物

生成物 1

HCID 59483827HCID 59483827、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

TFA (2.5 ml) was added to a cooled (0° C.) solution of tert-butyl 2-(9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecane-3-carbonyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (0.86 mmol, 1.0 equiv.) in DCM (10 ml), and the mixture was stirred for 2 h at 25° C. When the reaction was complete (TLC monitoring), the solvent was removed in vacuo in order thus to yield the desired product in the form of a yellow solid. This was used directly in the next stage without further purification.

後処理

  1. customthe solvent was removed in vacuo in order thus

出典と根拠

ORDレコード
ord-b8f78a2a3c834e5f826b1241562cf0cc
出典データセット
uspto-grants-2013_01
特許番号
US08357717B2

反応ノート

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